Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence

A study carried out by scientists Chhavi SharmaPooja SuhalkaPiyu SukhwalNeha Jaiswal, and Maheep Bhatnagar showed that curcumin, “an active ingredient of turmeric,” attenuates neurotoxicity induced by fluoride. Curcumin is known to have multiple benefits, including being an antioxidant, and it has also been suggested to be useful in the treatment of several neurological diseases.

The study used adult mice, which were divided into two groups. Group I was made up of control animals, which were given mice chow and fluoride-free water ad libitum for 30 days. The other three groups were the experimental ones, into which mice were randomly divided and given selected dosages on the basis of pilot studies conducted in their laboratory. All mice were kept in the laboratory, and the treatments were given for 30 days to all the groups.

The scientists observed that fluoride crossed the blood brain barrier, accumulating “in mice hippocampal neuron cell bodies,” thus initiating a cascade of reactions that increased the oxidative stress that caused an increase in MDA [mass drug administration] content of brain tissue, which is an end product of LPO. After being treated with curcumin, there was a distinctive decrease in MDA level, compared to the group that was treated with fluoride. “This can be correlated with the fact that this phytochemical is capable of quenching oxygen free radicals such as superoxide anions and hydroxyl radicals, which are important for the initiation of LPO.”

From their laboratory, the scientists have also reported “neurodegenerative changes at the cytological level.”. Recent studies from their laboratory “reported first time that fluoride causes severe neurodegenerative changes in the brain, particularly in the hippocampus and cerebral cortex. Treatment with fluoride (120 ppm) for 1 month causes significant degeneration in the cells of the hippocampus of mice brains. These neurodegenerative changes are observed as dark cells, pyknotic cells, 5% cells showed reduced size, and few cells showed small or shrunken nucleus in CA1, CA3, and DG regions of the hippocampus, and in these regions, various degenerative changes were observed. Even the number of neuronal cells counted in a specific region was less in fluoride group animals as compared to the control group. In group III decrease in neurodegenerative effects was observed. it is evident by presence of fewer dark cells, cells with distorted shapes, etc., A significant increase in viable neuronal cell count was found when the results were compared with group II. Cresyl violet staining of curcumin group clearly showed control pattern of cellular morphology and distribution. Thus, curcumin protects the neuronal cell bodies in hippocampal area, offering neuroprotection. Furthermore, we have first time reported that co-treatment of curcumin (30 mg/kg B.W.) along with fluoride (120 ppm) for 30 days, can lower the risk of degeneration caused due to fluoride.”

This study thus demonstrated “that daily single dose of 120 ppm fluoride results in highly significant increases in the LPO as well as neurodegenerative changes in neuron cell bodies of selected hippocampal regions. Supplementation with curcumin significantly reduce the toxic effect of fluoride to near normal level by augmenting the antioxidant defense through its scavenging property and provide an evidence of having therapeutic role against oxidative stress mediated neurodegeneration.”

As you can see, there is evidence that fluoride is very harmful and toxic. “Fluoride is probably the first inorganic ion which drew attention of the scientific world for its toxic effects and now the fluoride toxicity through drinking water is well-recognized as a global problem”, except for the British government. “Health effect reports on fluoride exposure also include various cancers, adverse reproductive activities, cardiovascular, and neurological diseases. Major cause of fluoride induced neurological diseases is excitotoxicity causing degeneration of neuron cell bodies in selective brain areas.”

Everything we need is found in nature, and everything that God gave us in nature can heal us from the poison of Big Pharma and governments.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969660/

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